Fat cells weaken the immune response and interfere with metabolic
In the case of obesity, the fat can cause the cells of a complex inflammatory chain reaction, which interferes with the metabolism and the immune weaknesses reaction. This can affect a variety of diseases, the course of negative.
In a recent joint study by the University of Cincinnati College of Medicine and Cincinnati s Hospital Medical Center Children’it was found that the fat cells of people with obesity is an inflammatory chain that can trigger a reaction, which favors a worse course of certain diseases. The results of the study were published in the English scientific journal “Nature Communications”.
What I interferons are type?
So-called type-I interferons are normally produced by immune cells. Interferons may also be produced by fat cells (adipocytes). These interferons cause a constant weak immune response, which amplifies the inflammatory cycle in white adipose tissue.
Inflammation triggers a cascade of cellular reactions
Such inflammation seems to be, in turn, a cascade of cellular reactions, the obesity-related diseases, in particular type 2 Diabetes and non-alcoholic fatty liver diseases is promoted.
Negative effects of type I Interferon
The results of the current study illustrate how type I Interferon, which is perceived by adipocytes, the inflammation supported potential. Thus, the obesity associated with metabolic reinforced disorders. In addition, the results underline a previously under-appreciated role of the adipocyte as a contributor to the overall inflammation in obesity, reports the researchers.
Type 1 interferons have a major influence on inflammation
The current study shows how type 1 interferons with IFNa receptor (IFNAR) to interact, creating a veritable vicious circle of inflammation is triggered. To include the effects of changes in the Expression of several genes, which are associated with inflammation, glycolysis and fatty acid production, for example. For example, mice, which are obesity-causing, took the diet, showed an increased type I IFN signature, including increased Expression of the genes Ifnb1, Ifnar1, Oas1a, and Isg15.
What the findings suggest?
It was shown that the type I Interferon axis can alter the inflammation programming of the adipocyte nucleus so that the cell approaches an inflammatory Immune, explains the research group. In addition, type I interferons modify the metabolism of the adipocytes, which seems to be the first representation of an immune-mediated Modulation of metabolism in the core of the adipocytes present, report the researchers.
Obesity can increase the risk for preterm birth
The interaction between obesity and the immune system seems to increase according to the statement of the research teams, the risk of a premature birth. This interaction reduces the body’s ability to fight infection, including viruses such as in the case of a disease by COVID-19.
Further research is already being carried out
Further research deals with the investigation of the specific mechanisms, the type I interferons use for the Modulation of the core metabolism of adipocytes. In addition, the researchers examine how adipocytes the abilities of inflammatory immune cells to be able to imitate. (as)
Authors and source of information
This Text meets the requirements of the medical literature, medical guidelines, as well as current studies and was examined by doctors and Medical scientists.