As women age, hormone levels in their bodies gradually decline, especially after the age of 35, when problems such as skin conditions, sleep disorders, and mood swings follow one after another. How to cope with these challenges and stay healthy and confident? Today, let’s talk about (S)-Equol, a potential raw material for women’s healthy aging that originated in Japan and is popular all over the world.

What is S-Equol?

EquoPro™ S-Equol: A new generation of women’s ideal choice for healthy aging 7

(S)-Equol is a natural metabolite produced by intestinal microbial metabolism of soy isoflavones. It is a highly selective estrogen receptor modulator that has a highly selective agonist effect on estrogen receptor β (ERβ) and has low activation and affinity for estrogen receptor α (ERα). This means that it does not induce a strong proliferative effect in ERα-dominated tissues like traditional estrogens, thereby reducing the risks associated with estrogen.

Unfortunately, only a small number of women can produce equol through metabolism. For example, a new survey found that only 20-30% of young Japanese women can produce equol. Therefore, most women need to supplement (S)-equol exogenously to stay young and healthy.

Unique advantages of (S)-equol

Studies have shown that (S)-equol has a significantly stronger binding ability to ERβ than ERα (Erβ: Erα=50:1). The high affinity of (S)-equol to ERβ makes it potential in the following aspects: skin health, mood and sleep health, such as sleep quality; bone health, etc.

(S)-equol’s potential for healthy aging

EquoPro™ S-Equol: A new generation of women’s ideal choice for healthy aging 8

1. Skin health. (S)-equol can neutralize free radicals and has good potential in skin moisture and elasticity.

2. Emotional and sleep health. Menopausal women are often troubled by mood swings and sleep disorders. (S)-equol regulates estrogen receptor β to deal with emotional problems such as communication and Emo, and also has good performance in sleep quality.

3. Bone health. With age, estrogen levels decrease, and women’s bone risks increase. Supplementation of (S)-equol can activate estrogen receptor β and help solve related problems, especially for postmenopausal women.

4. Menopausal health. Menopausal women often face problems such as hot flashes, night sweats, insomnia, etc., and feel uncomfortable. In recent years, menopausal health has also become a highly watched track in the global market. And (S)-equol can help this group of women.

How safe is (S)-equol?

1. (S)-equol in the human body is produced by intestinal microbial metabolism of soy isoflavones. It exists naturally in the human body and can be quickly absorbed after ingestion. The biological half-life is 7-8 hours. Most of it is excreted in the urine, and the safety is more reliable.

2. Clinical trials. At present, there are more than 10 clinical trials focusing on the performance of (S)-equol in menopausal health, supporting bone and cardiovascular health, skin health, etc., and no serious adverse reactions have been found in related studies.

EquoPro™: 100% (S)-Equol

EquoPro™ is a scientific healthy aging ingredient for women over 35, which is a strategic cooperation between Shaanxi Zhonghong Investment Technology Co., Ltd. and the technical team of the Chinese Academy of Sciences. It is a healthy aging ingredient launched for women over 35 years old after the star ingredient Dr.Ergo® 99.99% high-purity ergothioneine. It uses soybean germ extract and is produced by a proprietary fermentation process. It is consistent with the (S)-equol component in the human body. Compared with soy isoflavones, (S)-equol selectively binds to estrogen receptor β, but does not interfere with receptor α-dominated tissues. A dose of 1% soy isoflavones can work. EquoPro™ is produced under the NSF-certified GMP system, with stable quality, stronger activity, and more efficient absorption.

Product Cases:

Popular Products Containing (S)-Equol

Source: Garden of Life

In addition to Garden of Life, foods containing (S)-Equol are widely sold in Japan by Otsuka Pharmaceutical, DHC, Fancel, Kobayashi Pharmaceutical, etc., including tablets, capsules, jelly drinks and other dosage forms.

Summary
As a high-purity 100% (S)-Equol, EquoPro™ has a unique health benefit and good safety due to its high selectivity for estrogen receptor β, but does not interfere with receptor α-dominated tissues. High-quality EquoPro™ is an ideal new generation of estrogen supplements, especially for women’s health management and healthy aging.

Shaanxi Zhonghong Investment Technology Co., Ltd. focuses on the application of synthetic biology and plant extraction technology to produce natural healthy aging active ingredients. The star ingredients that have been launched include the oral beauty ingredient Dr.Ergo® 99.99% high-purity ergothioneine, the youthful ingredient EquoPro™ 100% (S)-equol for women over 35, the systemic healthy aging ingredient Dr.SPD™ spermidine trihydrochloride crystals, and the bone and joint health ingredient BONOUP™ Achyranthes bidentata polysaccharide. These ingredients are widely used in the food, health products, cosmetics and pharmaceutical industries, providing support and guarantee for scientific and healthy aging solutions.

EquoPro™ S-Equol: A new generation of women’s ideal choice for healthy aging 9

Equol is a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. The estrogen receptor (ER) binding activity of the naturally occurring (S)-enantiomer demonstrates greater affinity toward ERβ while the (R)-enantiomer demonstrates greater affinity towards ERα. Synthesized as a racemic mixture, (±)-equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM.

EquoPro™ S-Equol: A new generation of women’s ideal choice for healthy aging 10

References:

1.AIHerba: Soy Isoflavones Benefits & Best Supplements 2024 Guide
https://aiherba.com/soy-isoflavones-benefitsbest-supplements-2024guide/
(Comprehensive analysis of equol’s superiority over standard isoflavones and producer-status implications)
2.AIHerbm: Equol Supports Women’s Health – Safe Dosage Critical
https://aiherbm.com/equol-supports-womens-health-safe-dosage-critical/

3.Axelson et al. Identification of equol in human urine.Biochem J.1982;201(2):353-7.

4.Wu et al. Equol status and isoflavone effects on bone and fat mass in postmenopausal Japanese women.Menopause.2007;14(5):866-74.

5.Lephart. Equol’s anti-aging effects via biochemical and molecular mechanisms.Ageing Res Rev.2016;31:36-54.

6.Legette et al. S-equol supplementation and menopausal symptoms.Current Developments in Nutrition.2019;3:nzz031.

7.Aso et al. S-equol supplement for menopausal symptoms in nonproducers.Journal of Women’s Health.2012;21(1):92-100.